A paucity of heterochromatin at functional human neocentromeres
نویسندگان
چکیده
منابع مشابه
Neocentromeres
Do neocentromeres lead to disease? Not necessarily. What they do is stabilize chromosome fragments that would have otherwise been lost from daughter cells during cell division. Thus, it could be for some individuals that cells (or embryos) would have died due to chromosome loss if a neocentromere had not formed following inactivation of the natural centromere. Furthermore, centromere inactivati...
متن کاملFive novel locations of Neocentromeres in human: 18q22.1, Xq27.1∼27.2, Acro p13, Acro p12, and heterochromatin of unknown origin.
Since the first report in 1993, an ectopic centromere, i.e. neocentromere formation, has been reported in more than 100 small supernumerary marker chromosomes (sSMC), in 7 instances of centromere repositioning, and in about a dozen cases with more complex chromosomal rearrangements. Here we report 2 new cases with centromere repositioning and 3 neocentric sSMC consisting exclusively of heteroch...
متن کاملNeocentromeres and alpha satellite: a proposed structural code for functional human centromere DNA.
A comparative analysis of the conserved region of primate alpha satellite DNA and of a human neocentromere is reported. The two types of centromere DNA share structural features, possibly defining mitotically functional human centromere DNA. These features consist of double dyad symmetries of a particular size, as well as short conserved base motifs adjacent to the dyad symmetries. The possible...
متن کاملNeocentromeres Come of Age
Sixteen years ago, the discovery of a newly formed, ectopic centromere in a human [1,2] was a turning point for centromere research. Whereas previously centromeres had been thought of as immovable and unchanging, embedded in vast tracts of tandemly repeated DNA, this new centromere—or neocentromere—lacked any characteristic centromeric DNA sequences and had formed in a gene-rich area of the gen...
متن کاملNeocentromeres Form Efficiently at Multiple Possible Loci in Candida albicans
Centromeres are critically important for chromosome stability and integrity. Most eukaryotes have regional centromeres that include long tracts of repetitive DNA packaged into pericentric heterochromatin. Neocentromeres, new sites of functional kinetochore assembly, can form at ectopic loci because no DNA sequence is strictly required for assembly of a functional kinetochore. In humans, neocent...
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ژورنال
عنوان ژورنال: Epigenetics & Chromatin
سال: 2010
ISSN: 1756-8935
DOI: 10.1186/1756-8935-3-6